Keynote Lecture Series

Michael Levine

1:05:20

Mechanisms of transcriptional precision in the Drosophila embryo

Weizhe Hong

45:48

Larry Katz Lecture

Bob Kingston

56:50

Oligodendroglial metabolism and the support of axonal intergrity

Marie-Anne Felix

42:37

Natural populations of Caenorhabditis and studies on apparent and cryptic phenotypic variation

Philip Ingham

1:05:26

Two decades of sonic hedgehog

John Gurdon

1:02:12

The stabilization of cell differentiation

David Lane

1:46:56

Analysis of the p53 pathway in zebrafish

Steven Henikoff

Mapping genome-wide nucleosome dynamics

Susan Wessler

41:19

The success strategies of transposable elements that rapidly diversify genomes

Maxine Linial

1:09:17

40 Years in Retrovirology, a Reminiscence

Jonathan Stoye

54:19

Germ line retroviruses-good or bad?

John Mellors

1:14:49

Can HIV-1 be eradicated from the individual and the world?

Stefan Lohmander

1:50:48

Osteoarthritis —Understanding a common complex disease

Charles Sherr

46:09

Keynote Lecture

Jennifer Doudna

49:15

Programmable RNA-guided genome defense in bacteria

Adrian Bird

41:42

The dinucleotide CG as a genomic signalling module

Yuh-Nung Jan

29:58

Identification and studies of mechano-transduction channels in Drosophila

Lily Jan

29:45

Recent studies of potassium channels and a novel family of calcium-activated anion channels and cation channels

Lucy Shaprio

53:28

An integrated 3D network controls a bacterial cell cycle

Zhu Chen

52:01

Synergistic targeting therapies against oncoproteins for acute myeloid leukemia

Stephan Baylin

45:02

The era of the cancer epigenome: Dissecting the biological and translational implications

Carlo Croce

47:10

Causes and consequences of microRNA dysregulation in cancer

Retta Beery

35:48

The Beery Family Journey—A sequencing success

Carlo Croce

50:10

MicroRNAs can function as ligands for TLR and regulate the interactions between cancer cells and their microenviroment

Maynard Olson

45:06

Three cautions about personalized medicine

Clifford Tabin

40:36

Gut morphogenesis—From physical forces to localization of stem cells

Eric Schadt

1:02:30

Considering the digital Universe of data to better diagnose and treat patients

Eric Lander

1:02:58

Keynote Lecture

Tom Rapoport

58:44

Mechanisms of protein translocation across membranes

Reinhard Jahn

52:49

Exocytosis in neurons—Interplay between proteins and lipids

Warner Greene

1:11:20

T cell death and chronic inflammation: An unexpected link in HIV infection

Ben Berkhout

1:08:29

HIV RNAAAAAAA

Robert Farese

50:26

The roots of obesity—Mechanisms of lipid synthesis and storage

Hidde Ploegh

58:22

The Logic of Your Immune System

Edmund Rolls

1:05:25

“On the rules of cortical wiring and function, with implications for understanding psychiatric disorders”

Michael Brown

1:18:37

SCAP: Sensor of Membrane Cholesterol

Stefan Hell

1:09:37

Nanoscopy with focused light

Rudolf Jaenisch

1:01:01

Stem cells and pluripotency—Mechanisms of reprogramming and gene targeting in ES cells and mice

Leroy Hood

How systems medicine is changing healthcare

Jan Melom

59:39

Visualizing calcium—Insights into quantal synaptic transmission and cortex glial function

Joel Sussman

47:58

Proteopedia—A scientific 'Wiki' bridging the rift between 3D structure and function of biomacromolecules

Richard A. Young

1:08:44

Super-enhancers and the control of cell identity and disease

Eric Nestler

1:06:24

New insight into the neurobiology of depression

Lior Pachter

46:40

Stories from the Supplement

Hugh Reinhoff

33:07

My daughter's DNA and every little thing about her?

Richard Durbin

50:11

Some thoughts on ever more available sequencing

Michel Nussenzweig

55:25

Harnessing immunity to prevent and treat HIV infection

Ross Hardison

1:01:11

Genomics of hematopoietic gene regulation

Jacob Howard

53:57

How do you get rat research support in world of GWAS and whole genome sequencing in humans?

David Burt

46:02

Avian genomics a decade after the publication of the chicken genome sequence

Ramon Parsons

45:56

Keynote address

Hidehiko Inagaki

1:06

Neuronal mechanism of state control in Drosophila melanogaster

Peter Donnelly

48:29

Genomic Discovery: Mechanisms of Meiotic Recombination

Nancy Moran

45:31

Genomic Erosion in Symbiotic Bacteria

Mary Carrington

1:05:23

The influence of immunogenetic variation on HIV disease

David Moore

47:18

Targeting CAR to Treat and Prevent Liver Cancer

Rui Costa

1:03:28

Generating and shaping novel action repertoires

Stephen Harrison

1:01:15

Membrane dynamics and virus entry—From atomic structures to single-molecule movies

Keiichi Namba

57.11

CryoEM image analysis of macromolecular motor assemblies

Wolfgang Baumeister

55:00

Unveiling the long-held secrets of the 26S proteasome

Loren Looger

Tools for studying neurons, the only important cells in the brain

Gerard Evan

47:31

Targeting cancer’s engines, not its drivers

Arnold Levine

47:28

The evolution of thymic lymphomas in P53 knock-out mice

Fred Winston

44:15

Analysis of the role of Spt6 in controlling transcriptional accuracy in yeast

Toshio Matsumoto

59:35

Progress and perspectives of osteoporosis treatment

Paul Bieniasz

1:11:39

Keynote Speaker

David Haussler

1:33:12

Global exchange of human genetic data for medicine and research

Laurie Zoloth

36:11

Truth and consequences—Reflections on ethical issues in synthetic biology

Christopher Voight

46:23

Pushing the scale of Genetic Engineering

Maiken Nedergaard

1:12:49

The Glymphatic System

Marc Kirschner

1:14:13

How biology optimizes both specificity and efficiency—Single molecule studies of ubiquitylation

Ivan Dikic

54:15

Ubiquitin and Autophagy Networks

Arul Chinnaiyan

1:06:04

The application of integrative sequencing for precision medicine

Gene Robinson

1:06:19

Transcriptional regulation and metabolism: key elements in the evolution and mechanisms of social life in bees

Judith Korb

51:07

Comparative transcriptomics reveals the modular organization of ant phenotypic traits

Laurent Keller

53:40

The influence of genes and social environment on behavior and social organization

Brenda Schulman

53:45

Celebrating the ubiquitin family;diversity of cullin-RING Ubl and Ub ligation mechanisms

George Davey Smith

56:07

Mendelian randomization:Harnessing genocopy/phenocopy to identify modifiable causes of disease

Francis Collins

50:58

From the HGP to Precision Medicine

Susan Ross

56:25

Using mouse genetics to study host-virus interactions

Svante Paabo

The Genetic Legacy of Neanderthals

Frank Slack

48:52

MicroRNAs in aging

Eric Shoubridge

Posttranscriptional regulation of mitochondrial gene expression

Alfred Goldberg

55:06

Regulation of proteasome function in normal and disease states

Alan Rein

1:01:02

Retroviruses; Some Perspectives

Robert Kingston

43:41

Nucleosome compaction as a regulatory mechanism during development

Aviv Regev

1:20:25

Towards a neuron cell atlas

Mingyang Lu

Interrogating the robustness of gene regulatory circuits by RACIPE

Marian Walhout

1:01:26

Gene Regulatory Networks

Marc Vidal

1:27:27

"Edgetics"

Anne Bertolotti

53:04

Maintaining proteasome homeostasis

Christopher Lima

52:16

Ubiquitin-like proteins:From conjugation to recognition

Andrew Clark

54:33

Junk Evolution

Stephen Hughes

1:11:52

Why study integration and reverse transcription

Craig Thompson

1:04:44

Manipulating cell death—The discovery and preclinical development of Bcl-2 inhibitors

Raphael Cohn

52:46

Circuit mechanisms for flexible sensorimotor processing in Drosophila

Michael Karin

59:23

De novo lipogenesis induced by ER stress is essential for hepatic steatosis and its progression to NASH

Elaine R. Mardis

49:51

PERSONALIZED CANCER GENOMICS: IMPACT AND IMPLICATIONS

Maricel Kann

58:12

“A protein-domain approach for the analysis of disease mutations”

Lior Pachter

1:01:34

“Post-procrustean bioinformatics”

Edward Boyden

1:13:29

"Optical tools for analyzing and repairing complex biological systems"

Ellen Rothenberg

1:27:53

"Dissection of the regulatory trajectory for early T-cell lineage commitment"

Svante Paabo

1:06:51

"Using ancient genomes and model systems to study uniquely human phenotypes"

Insoo Hyun

56:21

"3D models of the human brain—What are the ethical concerns and how should they be addressed?"

Geeta Narlikar

50:05

Understanding the biochemical and biophysical basis for genome organization

Steven Henikoff

51:47

Structural epigenomics (precision mapping of the chromatin landscape)

Junying Yuan

46:50

Ubiquitination regulated RIPK1 activation controls apoptosis and necroptosis

Justus Kebschull

57:56

Exploiting DNA sequencing technology for high-throughput neuroanatomy

Rudolf Jaenisch

48:25

Stem cells and epigenetic regulation in development and disease

David Page

50:23

Sex differences in health and disease

Craig Pikaard

42:29

Mechanisms of selective gene silencing

Henrich Gottlinger

1:18:07

HIV release and infectivity—From ESCRTs to SERINCs

P.Read Montague

1:03:50

Connecting mind and brain in a computational age

Lee Zou

46:18

Targeting the aberrant R-Loop accumulation in cancer cells with ATR inhibitors

Joan Brugge

Oxidative Stress Defenses in Cancer

Antonio Giraldez

Elucidating the interplay between RNA sequence, structure and translation regulation during vertebrate embryogenesis

Matthew State

56:17

Lost in translation—Moving from de novo mutations to pathophysiology

Eric Betzig

1:02:37

Imaging cellular structure and dynamics from molecules to organisms

Cedric Feschotte

Transposable elements as catalysts of cellular innovation

Josh Dubnau

Retrotransposon storm hypothesis of ALS—The dangers of a Collyer's genome

Blake Wiedenheft

Evolutionary outcomes of CRISPR-anti-CRISPR conflict

Katherine Pollard

Population genetic models for human associated microbes

Matthew Stephens

Lessons learned—Reflections on some research projects in computational biology, where they came from, and where they went